6th of October
- 9.00-9.10 Opening address – Tomasz Rzymkowski - Ministry of Education and Science, Andrzej Kawecki (NRIO, Warsaw), Michał Mikula (NRIO, Warsaw).
- 9.10-9.40 Opening lecture – Mien-Chie Hung (China Medical Univ.Taichung, Taiwan): Marker-guided target cancer therapy
Session: CAR-T as modern adopitve therapy
Chairs: Zygmunt Pojda & Radosław Zagożdżon
- 9.40-10.00 Radosław Zagożdżon (WUM Warsaw): PD-L1 molecule as a potential target for anticancer CAR-T immunotherapy
- 10.00-10.20 Zygmunt Pojda (NRIO Warsaw): Decentralized versus centralized CAR-T production - pros and contras.
- 10.20-10.40 Sébastien Walchli (Oslo University Hospital, Oslo): Surprises and challenges in CAR development: the interesting case of CD37CAR
- 10.40-11.00 Halvard Boening: Finding one's niche in the CAR arena.
- 11.00-11.10 Coffee break
Session: Molecular diagnostics and markers in cancer,
Chairs: Andrzej Tysarowski & Janusz Siedlecki
Session patron AstraZeneca
- 11.10-11.30 Andrzej Tysarowski (NRIO, Warsaw): Application of Molecular Biology Methods in Oncological Diagnostics
- 11.30-11.50 Małgorzata Oczko-Wojciechowska (NRIO, Gliwice): The role of molecular tests in preoperative diagnostics of thyroid cancer.
- 11.50-12.10 Beata Jagielska : (Prezes Polskiej Koalicji Medycyny Personalizowanej) What will be requirements around matching a specific diagnostic test with a specific therapy based on lung cancer
- 12.10-12.30 Andrzej Nowakowski (NRIO, Warsaw): The use of novel technologies in cervical cancer screening – the Polish perspective
- 12.30-12.45 Monika Słowińska (NRIO, Warsaw): An In Vivo Visualization Of Cutaneous Squamous Cell Carcinoma Microenvironment Under Immunotherapy using Reflectance Confocal Microscopy.
- 12.45-13.00 Coffee break
Session: Molecular Biology and Cancer
Chairs: Piotr Widłak & Ewa Grzybowska
- 13.00-13.20 Wiesława Widłak (NRIO, Gliwice): How Heat Shock Factor 1 (HSF1) prevents inflammation under stress?
- 13.20-13.40 Dorota Ścieglińska (NRIO, Gliwice): The role of Heat Shock Protein A2 in the regulation of human epidermal homeostasis.
- 13.40-14.00 Marek Rusin (NRIO, Gliwice): Transcriptomic and proteomic study of cancer cell lines exposed to actinomycin D and nutlin-3a reveals numerous, novel candidates for p53-regulated genes.
- 14.00-14.20 Anna Wojakowska (Institute of Bioorganic Chemistry, Poznań): Proteomic and metabolomic profiling of serum exosomes from cancer patients treated by ionizing radiation.
- 14.20-14.40 Natalia Marek-Trzonkowska (University of Gdańsk): Immune response in non-small cell lung cancer and perspectives for immunotherapy.
- 14.40-15.00 Lunch
Session: Chromatin and epigenetics
Chairs: Tomasz Sarnowski & Richard Bayliss
- 15.00-15.20 Tomasz Turowski (IBB PAS, Warsaw): Targeting RNA polymerase I – mechanistic link between transcription,r-loops and DNA instability.
- 15.20-15.40 Richard Bayliss (Leeds University, UK): A moving target: in pursuit of Myc inhibitors
- 15.40-15.50 Agnieszka Robaszkiewicz (UŁ, Łódź): The role of chromatin remodelling complex SWI/SNF in gaining cancer drug resistance during paclitaxel-based chemotherapy
- 15.50-16.10 Gabriele Büchel (University Hospital Würzburg, Germany): Inducing transcription–replication conflicts as a therapy in neuroblastoma.
- 16.10-16.40 Special guest Jay Berzofsky (NCI, Bethesda, USA): Cancer vaccine studies from bench to bedside and back to the bench.
- 16.40-17.10 Coffee break and poster session
Session: Recent advances in molecular biology of thyroid cancer
Chair: Damian Gaweł & Marlena Godlewska
- 17.10-17.30 Marlena Godlewska (CMKP, Warsaw): Role of FERM family proteins in thyroid cancer.
- 17.30-17.50 Małgorzata Grzanka: (CMKP, Warsaw): Role of extracellular vesicles in the progression of thyroid cancer.
- 17.50-18.10 Maciej Ratajczak: (CMKP, Warsaw): Kinase-targeted therapies in thyroid cancer: progress and challenges.
- 18.10-18.30 Dagmara Rusinek (NRIO, Gliwice): State of the art in the molecular prognostic factors in differentiated thyroid cancer.
- 19.00 Dinner
7th of October
Session: Prostate cancer
Chair: Alfonso Urbanucci & Paweł Wiechno
- 9.00-9.20 Mateusz Dąbkowski (NRIO, Warszawa): How irradiation of the primary affects course of dissease in metastatic prostate cancer patients.
- 9.20-9.40 Alfonso Urbanucci (Oslo University Hospital, Oslo): Single-cell analysis and spatial transcriptomics reveal insights into (prostate) cancer relapse.
- 9.40-10.00 Pawel Wiechno (NRIO, Warsaw): Prostate cancer - is it always better to diagnose and treat earlier?
- 10.00-10.30 Three the best abstracts will be selected for 10 min prsentation.
- 10.30-10.40 Coffee break
Session: Biology of head and neck cancer
Chairs: Monika Pietrowska & Piotr Widłak
- 10.40-11.00 Tomasz Rutkowski (NRIO, Gliwice): HPV related and not related oropharyngeal cancer. Patients characteristic and treatment results in material of NRIO Gliwice.
- 11.00-11.20 Agnieszka Mazurek (NRIO, Gliwice): Circulating HPV16 DNA in the management of patients with oropharyngeal cancer - practical application.
- 11.20-11.40 Beata Biesaga (NRIO, Kraków): New prognostic indicators in HPV‑positive oropharyngeal cancer. [on-line]
- 11.40-11.55 Dirk Biskup (CeGaT GmbH, Tuebingen), Precision Diagnostics and Precision Medicine.
- 11.55-12.15 Piotr Widłak (MUG, Gdańsk): Exosomes - mediators of signals released by head and neck cancer cells.
- 12.15-12.35 Jadwiga Jabłońska (University Hospital, Essen): Neutrophil-mediated immunoregulation during head-and-neck cancer progression: new APCs on the block.
- 12.35-12.55 Marta Gawin (NRIO, Gliwice): Mass Spectrometry Imaging of head and neck cancer.
- 12.55 - 13.10 Coffee break
Short oral presentation
- 13.10-13.40 six abstracts will be selected by the Scientific Committee for the spotlight presentation 5 min.
- 13.40 -14.10 Lunch
NRIO internal grant session
Chair: Michał Mikula
- 14.10-15.30 NRIO internal grant presentations
- 15.30-16.00 Closing lecture Theresa Whiteside: (Pittsburgh University, USA): Tumor-derived exosomes and their role as potential biomarkers of cancer progression.
- 16.00 Closing remarks