The 6th Warsaw Conference on Perspectives of Molecular Oncology
15-16 September 2021
15th of September
10.00 - 10.15 Opening address – Jan Walewski (NIO-PIB, Warszawa)
Paweł Kukołowicz (NIO-PIB Warszawa) About Maria Sklodowska-Curie National Research Institute of Oncology in Poland.
Session: Molecular Biology of Cancer
Chairs: Piotr Widłak & Katarzyna Lisowska
10.15 - 10.45 Olaf Heidenreich (Princess Maxima Center, Utrecht, Netherlands): Killing the culprit: Therapeutic targeting of fusion gene function
10.45 - 11.05 Piotr Widłak (NRIO, Gliwice): Intratumor-heterogeneity assessed by mass spectrometry imaging – association with cancer prognosis.
11.05 - 11.25 Agnieszka Piekiełko – Witkowska (Centre of Postgraduate Medical Education, Warsaw) Dysfunctions of thyroid gland and breast cancer: random coincidence or a casual link?
11.25 – 11.45 Magdalena Olbryt (NRIO, Gliwice): Genetic profiling of melanoma
11.45- 12.00 Coffee break
12.00 - 12.20 Nils Ludwig (University Hospital Regensburg, Germany): Role of TGF-β in tumor cell-derived small extracellular vesicles in promoting tumor growth and angiogenesis in head and neck squamous cell carcinoma.
12.20 - 12.40 Monika Pietrowska (NRIO, Gliwice): Immunomodulatory properties of tumor-derived exosomes from HPV-dependent and HPV-independent head and neck cancers.
12.40 - 13.00 Agnieszka Mazurek (NRIO, Gliwice): Circulating HPV DNA (ctHPV) - a new generation plasma-based biomarker as a challenge for modern diagnostics.
13.00 - 14.00 Lunch
14.00 - 14.20 Marek Rusin (NRIO, Gliwice): The p53 protein - activator or inhibitor of interferon signaling system?
14.20 - 14.40 Wiesława Widłak (NRIO, Gliwice): The cross-talk between estrogen receptor and HSF1 in breast cancer.
14.40 - 15.00 Dorota Ścieglińska (NRIO, Gliwice): HSPAs as therapeutic targets in lung cancer.
15.00 - 15.30 Hilary Kenny (University of Chicago, Chicago, USA): 3D Modeling the Ovarian Cancer Tumor Microenvironment
15.30 - 16.00 Grant McFadden (School of Life Sciences, Arizona State University, Phoenix, USA): Ex vivo oncolytic virotherapy with myxoma virus.
16.00 – 16.15 Coffee break
Session: Application of low doses of ionizing radiation in medical therapies
Chairs: Dorota Słonina & Tomasz Rutkowski
16.15 – 16.45 Nicolas Foray (INSERM Unit U1296 Radiation: Defense, Health, Environment, Lyon, France): The radiation-induced nucleoshuttling of the ATM protein and its medical applications at low doses"
16.45 – 17.05 Dorota Słonina (NIO, Gliwice): An overview of the rationale of low-dose radiotherapy.
17.05 - 17.25 Tomasz Rutkowski (NIO, Gliwice): Low-dose fractionated radiation with induction chemotherapy for locally advanced head and neck cancer. A prospective phase II study.
17.25 - 17.45 Jerzy Jaroszewicz (Szpital Specjalistyczny Nr 1, Bytom): Low dose whole lung radiotherapy for COVID-19.
17.45 - 18.05 Krzysztof Ślosarek (NIO, Gliwice): Dose estimation based on fluence map for SARS-COVID radiotherapy
18.05 - 18.25 Tomasz Latusek (NIO, Gliwice): The less is better in radiotherapy for the selected non-malignant diseases
19.00 - Dinner
16th of September
Session: Molecular diagnosis in cancer
Chairs: Andrzej Tysarowski & Janusz Siedlecki
9.00 - 9.20 Andrzej Tysarowski (NIO-PIB Warszawa) Application of Molecular Biology Methods in Oncological Diagnostics
9.20 - 9.40 Anna Raciborska (IMID Warszawa) MOLECULAR TEST AND TRANSLATIONAL SCIENCE IN CHILD CANCER
9.40 - 10.00 Beata Jagielska (Prezes Polskiej Koalicji Medycyny Personalizowanej) What will be requirements around matching a specific diagnostic test with a specific therapy based on lung cancer
10.00 - 10.20 Andrzej Nowakowski (NIO-PIB Warszawa) The use of novel technologies in cervical cancer screening – the Polish perspective
10.20 - 10.40 Dorota Nowakowska (NIO-PIB Warszawa) Integrating Germline and Tumour Genomic Data Into Oncology Practice and Genetic Counselling
10.40- 10.45 Coffe break
Sesja sponsorowana
10.45- 11.05 Sonia Konicz & Adam Olejnik (Roche Diagnostics - wyklad sponsora) Kompleksowa diagnostyka molekularna w onkologii
11.05 - 11.20 Coffee break
Session: Chromatin and epigenetics
Chairs: Janusz Siedlecki & Tomasz Sarnowski
11.20 - 11.40 Damian Gaweł (Centre of Postgraduate Medical Education, Warsaw) MicroRNA and nanoparticles - combinatorial strategy for cancer treatment
11.40 – 12.00 Richard Bayliss (University of Leeds, UK) Regulation of MYCN function by Aurora-A kinase
12.00- 12.20 Alfonso Urbanucci (Oslo University Hospital, Norway) The dysregulation of chromatin structure in prostate cancer initiation and progression
12.20 – 12.40 Antoniolli Martina (Ludwig-Maximilians- University Hospital of Munich, Germany) ARID1A Controls a Novel Transcriptional Network Regulating FAS in Follicular Lymphoma
12.40 – 13.00 Agnieszka Ciesielska (Science & Technology Advisor, 10x Genomics - wyklad sponsorski) Transkryptomika przestrzenna oraz analiza pojedynczej komórki - nowatorskie podejścia badawcze w onkologii.
13.00- 13.20 Krzysztof Książek (Medical University, Poznań): The role of cellular senescence in the development of intraperitoneal ovarian cancer metastasis.
13.20 – 13.40 Lunch
13.40 - 14.30 Short oral presentations
Chair: Szymon Kubala & Alfonso Urbanucci
Maciej Ambroziak (5 min) Identification of CD30-binding VHH from immunologically naïve alpacas.
Szostakowska-Rodzoś (5min) Epithelial – Mesenchymal Plasticity of Brest Cancer Stem-like Cells
Gaweł Agata (5min) Analysis of factors regulating the process of entosis in cancer cells.
Smolarczyk Ryszard (10 min) Combination of the STING protein agonist (cGAMP) and the anti-vascular agent - combretastatin - as an effective murine breast cancer therapy.
Grzybowska Ewa (10 min) Genetic and Phenotypic Heterogeneity of Circulating Tumor Cells in Metastatic Breast Cancer Patients.
Ewelina Pilny (5 min) The influence of Interleukin 6 on bone marrow macrophages.
Joanna Jazowiecka-Rakus (5 min) Myxoma Virus Expressing LIGHT (TNFSF14) Pre-Loaded into Adipose-Derived Mesenchymal Stem Cells is Effective Treatment for Murine Pancreatic Adenocarcinoma
Jarosław Steciuk (5min) SWI/SNF subunits as candidates for cancer treatment based on synthetic lethality
14.30- 14.50 – Closing lecture Tomasz Sarnowski (Institute of Biochemistry and Biophysics PAS, Warsaw) M13 bacteriophage and anti-SARS-CoV-2 VHH as a potentaial therapy against COVID19 - Polish Research Medical Agency project.
14.50 – 15.00 Closing remarks and panel discussion: Why scientist should get a trainning in other Institutes/Universities?