Scientific programme

The 5th Warsaw Conference on Perspectives of Molecular Oncology:

2020 -  Molecular Immunology of Cancer

September 23rd, 2020


9.15 – 9.30                  Opening

Opening address – Jan Walewski (NIO-PIB, Warszawa)


9.30 – 11.00                Session „Exosomes in Immunity and Cancer” (part 1)


9.30-10.00 Katalin Lumniczky (National Public Health Institute, Budapest): Extracellular vesicles participate in the development of ionizing radiation-induced bone marrow pathologies


10.00-10.20 Małgorzata Czystowska-Kuźmicz (WUM, Warszawa): Role of Arginase-1 containing EVs in the immunosuppression in ovarian cancer


10.20-10.40 Rafał Szatanek (UJ-CM, Kraków) Autologous tumor-derived microvesicles (auto-TMVs) in cross-talk between gastric cancer cells


10.40-11.00 Katarzyna Nazimek (UJ-CM, Kraków): Perspectives in manipulating EVs for therapeutic applications


11.00 – 11.30              Break


11.30 – 13.40              Session „Exosomes in Immunity and Cancer” (part 2)


11.30-11.50 Alicia Martinez Llorente (OUH, Oslo): Omics analyses of  extracellular vesicles for the discovery of prostate cancer biomarkers in urine


11.50-12.10 Marie-Nicole Theodoraki (University of Ulm, Ulm): Plasma-derived exosomes as liquid biomarkers in Head and Neck Cancer: facts and hopes


12.10-12.25 Małgorzata Przybyło (UJ, Kraków): EV glycoproteome as a source of biomarkers in melanoma


12.25-12.45 Markus Düchler (CMMS-PAN, Łódź): Melanoma induced antigen-specific immune tolerance – mediated by exosomes?


12.45-12.55 Joanna Rossowska (IITD-PAN, Wrocław): Modified tumor-derived exosomes as  potential vectors for delivery of anti-tumor molecules


12.55-13.15 Tadeusz Janas (UO, Opole): Mechanisms of selective RNA loading into exosomes


13.15-13.25 Rafał Mańka (UO, Opole): RNA aptamers containing EXO motifs exhibit enhanced affinity for membrane rafts


13.25-13.35 Dominika Maziarz (UO, Opole): Binding of Cholera toxin subunit B to exosomal liposomes


13.40 – 14.15              Break


14.15 – 16.15              Session „Exosomes in Immunity and Cancer” (part 3)


14.15-14.45 Theresa L. Whiteside (Pittsburgh University, Pittsburgh): Challenges in exosome isolation, characterization and translation in human health or disease


14.45-15.15 Janusz Rak (McGill University, Toronto): Oncogenic reprogramming of extracellular vesicles - implications for vascular responses and immunoregulation in cancer


15.15-15.30 Monika Pietrowska (NIO, Gliwice): Proteomic profile of tumor-derived exosomes in plasma of melanoma patients


15.30-15.45 Piotr Widłak (NIO, Gliwice): Role of EVs and their content in the radiation-mediated bystander effects


15.45-15.55 Anna Wojakowska (IBCh, Poznań): GC-MS- based metabolomic profiling of serum and exosomes isolated from head and neck cancer patients after radiotherapy


15.55-16.05 Agata Abramowicz (NIO, Gliwice): The protein cargo of extracellular vesicles released by head and neck cancer cells under hypoxia


16.05-16.15     General discussion and conclusions


September 24th, 2020


9.15-12.00                Session „Immunotherapy and Molecular Immunology of Cancer

9.15-9.30 Jadwiga Jablonska (University Hospital, Essen): Regulatory role of tumor-associated neutrophils during cancerogenesis: friends or foes?

9.30-9.45 Marta Miączyńska (IIMCB, Warsaw): Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer


9.45-10.00 Rafał Sądej (GUMED, Gdańsk): HER2-dependent response of DCIS cells to inflammatory stimuli)


10.00-10.15 Marek Rusin (NIO, Gliwice): The p53 as a regulator of immunity - fact or fake?

10.15-10.30 Magdalena Cybulska (NIO, Warszawa): Patient derived xenografts (PDX) immune and gut microbiota humanized models for oncology preclinical translational research


10.30-10.45                 Break


10.45-11.00 Radosław Zagożdżon (WUM, Warszawa): Perspectives of chimeric antigen receptor-based therapies in solid malignancies


11.00-11.15 Andrzej Mackiewicz (WCO, Poznań): Cellular and molecular mechanisms of therapeutic melanoma vaccination


11.15-11.30 Sebastian Giebel (NIO, Gliwice): Immunotherapy of acute lymphoblastic leukemia


11.30-11.45 Beata Jagielska (NIO, Warszawa): Cardiotoxicity implications in immunotherapy


11.45-12.00 Ryszard Smolarczyk (NIO, Gliwice): Vascular disrupting agents in anticancer therapy


12.00-12.15 Joanna Chorostowska-Wynimko (NTLDRI, Warszawa):  FGFR1 as the potential diagnostic and therapeutic target in squamous lung cancer


12.15-12.30 Stefan Chmielewski (Ryvu Therapeutics, Kraków): Novel small molecules in cancer immunotherapy


12.30-12.45 Jacek Plewka (UJ, Kraków): Monitoring Protein-Ligand Interactions with NMR and other biophysical assays: Inhibitors of the immune checkpoints PD-1/PD-1


12.45-13.00                 Break


13.00-15.30              Session „Molecular Oncology – Mechanisms and Applications


13.00-13.15 Alfonso Urbanucci (Oslo Hospital University, Oslo): Molecular dependencies of prostate cancer and melanoma for precision oncology


13.15-13.30 Richard Bayliss (University of Leeds, UK): Single domain antibodies are versatile tools in cancer biology


13.30-13.50 Bożena Kamińska (Nencki Institute, Warszawa): Characterization and targeting epigenetic dysfunctions in glioma


13.50-14.05 Elzbieta Speina (IBB, Warszawa): DNA repair capacity is increased in glioblastoma and cervical carcinoma cells resistant to photodynamic therapy

14.05-14.15                 Break


14.15-14.30  Paweł Kukołowicz (NIO, Warszawa): Personalized radiotherapy


14.30-15.45 Urszula Wojda (Nencki Institute, Warszawa): MicroRNA signatures in blood plasma reveal inverse molecular mechanisms in cancer and neurodegeneration

15.45-15.00 Dominik Domanski (IBB, Warszawa): The application of targeted mass spectrometry-based proteomics to lung and breast cancer diagnostics and therapy guidance


15.00-15.15 Break


15.15-17.00                Short oral presentation of awarded abstracts

Presentation no longer than 7 min.

Szymon Kubala (IBB, Warszawa): Aberration of SWI/SNF dependent chromatin remodeling and mRNA splicing may play important role in advanced adenoid cystic carcinoma (ACC) development and chemoresistance

Iga Jancewicz (NIO, Warszawa): The role of SWI/SNF chromatin remodelling complex ATPase subunit – BRM, in triple negative breast cancer

Jakkapong Kluebsoongnoen (Institute of Molecular Biosciences, Nakhon Pathom): The assessment of the role of the core SWI/SNF complex SMARCC2 subunit in steroid hormone pathway regulating ovarian development in Penaeus monodon

Katarzyna Leszczynska (Nencki Institute, Warszawa): Chromatin landscape of H3K27M pediatric high-grade gliomas in response to epigenetic treatments

Ewa Grzybowska (NIO, Gliwice): Modified signaling pathways in gene expression profiles of three histologic types of ovarian carcinoma

Joanna Szarkowska (NIO, Warszawa): Impairment of PBRM1 affects RRM genes expression in clear cell renal cell carcinoma

Małgorzata Stachowiak (NIO, Warszawa): Analysis of expression of vitamin D receptor and 1-α-hydroxylase in clear cell renal cell carcinoma

Joanna Bogusławska (CPME, Warszawa): TGF-β1-affected microRNAs regulate the expression of genes linked to clear cell renal cell cancer (ccRCC) cells proliferation, viability and migration

Dorota Ścieglińska (NIO, Gliwice): The redundancy of HSPA1, HSPA2 and other HSPA proteins in non-small cell lung carcinoma cells (NSCLC)

Karol Jelonek (NIO, Gliwice): Application of serum metabolome profiles in monitoring the systemic effects of concomitant chemo-radiotherapy and radiotherapy alone in head and neck cancer patients

Aleksandra Robak (IBB, Warszawa): Diagnosis of pleural effusions using mass spectrometry-based targeted proteomics